Human Sera
Cayman Chemical DapaglIflozIn 50mg
An SGLT2 inhibitor (IC50 = 1.12 and 3 nM for the human and rat enzymes, respectively); selective for SGLT2 over SGLT1 (IC50 = 1,391 and 620 nM for the human and rat enzymes, respectively) and human adipocyte GLUT activity at 20 µM; increases urinary glucose levels in normal and Zucker diabetic rats at 0.1 and 1 mg/kg; decreases fasting and fed plasma glucose levels in Zucker diabetic rats at 0.01, 0.1, and 1 mg/kg
Cayman Chemical PF-06650833 50mg
An IRAK4 inhibitor (IC50 = 0.2 nM); selective for IRAK4 over a panel of 268 kinases at 200 nM but also inhibits IRAK1, MNK2, LRRK2, Clk4, and CK1γ1 by >70% at 200 nM; reduces DNA secretion from R-837-stimulated primary human neutrophils and decreases R-848-induced IRF5 nuclear translocation in primary human PMBCs at 100 nM; decreases paw volume in a rat model of collagen-induced arthritis at 100 mg/kg once per day; reduces serum levels of anti-dsDNA, anti-SSA, and anti-RNP antibodies and decreases kidney glomerular tuft area in a mouse model of pristane-induced SLE
Cayman Chemical NMethylNnItrosopIperazIn 50mg
A potential impurity in various pharmaceutical preparations
Cayman Chemical LPhenylephrInhydroCLOrId 100mg
An adrenergic α1A receptor agonist (Ki = 1.4 µM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 µM, respectively); frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents
Cayman Chemical -LIquIrItIgenIn 50mg
A flavonoid with anticancer activity; cytotoxic to HL-60, HCT8, and B16 cancer cell lines (IC50s = 22.5, 19.5, and 5 μg/ml, respectively)
Cayman Chemical CntharIdIn 100mg
Inhibits PP1 (IC50 = 1.7 μM) and PP2A (IC50 = 0.2 μM) while only weakly inhibiting the activity of PP2B (IC50 = 1 mM); stimulates cell cycle progression and induces premature mitosis and has been shown to be active in various cancer cell lines
Cayman Chemical n-TrIacontnol 100mg
A plant growth regulator with plant growth-stimulating and antioxidant activities; increases the dry weight of barley, corn, and tomato seedlings in greenhouse pot tests at 0.001 and 0.01 mg/L; increases the photosynthetic rate in isolated pea protoplasts and pea seedlings at 1 µM; increases photosynthesis in pea protoplasts at 1.56 µM; an inhibitor of 1-LO (Ki = 5 µM for the soybean enzyme); decreases TBARS levels in isolated chloroplasts from spinach leaves at 120 nM
Cayman Chemical DocosapentaeNIc ACD mthyl 50mg
An esterified form of docosapentaenoic acid; has been used as a reference standard in the quantification of fatty acids in microalgal and fish oils
Cayman Chemical GSK205hydrobromIde 50mg
A TRPV4 and TRPA1 inhibitor (IC50s = 4.19 and 5.56, respectively, for the rat channels); inhibits GSK1016790A-induced calcium influx in whole-cell patch-clamp assays using Neuro2a cells expressing TRPV4 at 5 µM; prevents compression-induced increases in NF-κB transcriptional activity and secreted levels of IL-6 and VEGFA, as well as inhibits compression-induced fractures, abnormal cell morphology, and fissures in the intervertebral space, in primary mouse lumbar spines at 10 µM
Cayman Chemical 3 4MethylendIoxyNbenzylca 50mg
A substituted cathinone that is structurally analogous to methylone, a narcotic which is regulated in the United States; intended for research and forensic applications
Cayman Chemical ZalcItabIn 100mg
A NRTI; reduces the replication of laboratory-adapted and clinical isolates of HIV in a plaque reduction assay (IC50s = 0.013-0.08 µM)
Cayman Chemical Hexaflumuron 100mg
A chitin synthesis inhibitor that is used to bait and eliminate termite colonies; also effective against the raisin moth, cowpea weevil, and Asiatic rice borer
Cayman Chemical SB-224289hydrochlorIde 50mg
A potent 5-HT1B inverse agonist (pKi = 8.16) that displays >75-fold selectivity for human 5-HT1B over all other 5-HT receptors
Cayman Chemical GBR 12909hydrochlorIde 50mg
A potent inhibitor that blocks dopamine uptake (IC50 = 1-51 nM); effectively inhibits dopamine uptake in vivo, leading to consequent stimulation of dopamine receptors.