Human Sera
Cayman Chemical 1R 3S3Hydroxycyclopentn 50mg
A potent orally active inhibitor of LTA4 hydrolase that blocks ionophore-stimulated LTB4 synthesis in whole blood (IC50 49 nM) inhibits LTB4 biosynthesis without affecting LTC4 or 6-keto PGF1a production in a rat model of ionophore-induced peritoneal eicosanoid production
Cayman Chemical 1S 3R3Hydroxycyclopentn 50mg
An antagonist of the 5-HT2C receptor (pKi 9 0) with at least 100-fold more selectivity over other 5-HT dopamine or adrenergic receptors brain penetrant with significant anxiolytic activity used extensively in animal research
Cayman Chemical 4fluoro BZPhydrochLRIde 100mg
A pentacyclic triterpenoid with diverse biological activities inhibits the proliferation of HepG2 liver MCF-7 breast and Caco-2 colon cancer cells (EC50s 87 4 14 4 and 34 4 M respectively) reverses increases in hepatic steatosis levels of hepatic triglycerides and free fatty acids and hepatic TNF-a IL-1B IL-6 and IL-8 mRNA expression in a dose-dependent manner in a high-fat diet-induced rat model of NAFLD scavenges DPPH radicals (IC50 59 7 g/ml) inhibits the growth of several strains of Gram-positive and Gram-negative bacteria in vitro including S aureus E coli P aeruginosa K pneumoniae and S flexneri (MICs 32-512 g/ml)
Cayman Chemical 1R 3R3Hydroxycyclopentn 50mg
An antagonist of the 5-HT2C receptor (pKi 9 0) with at least 100-fold more selectivity over other 5-HT dopamine or adrenergic receptors brain penetrant with significant anxiolytic activity used extensively in animal research
Cayman Chemical 1S 3R3AmInocyclopentnol 50mg
15-deoxy-1214-Prostaglandin J2 (15-deoxy-1214-PGJ2 Item No 18570) is one of the cyclopentenone PGs which have documented metabolic (peroxisome proliferator-activated receptor Y-activating) antimitotic and antiproliferative effects 410134913037 The activity of the compounds in this class which includes PGs in both the A- and J-series may result from changes in gene expression and the interaction with non-classical (i e non-G protein-coupled receptor) pathways 15-deoxy- DELTA 1214-PGJ2-biotin is an affinity probe which allows 15-deoxy- DELTA 1214-PGJ2 to be detected through an interaction with the biotin ligand 15-deoxy- DELTA 1214-PGJ2-biotin was designed to allow 15-deoxy- DELTA 1214-PGJ2 to be detected in complexes with nuclear receptors and/or nucleic acid or protein binding partners It is thus a tool to be used in the general elucidation of the mechanism of action of the cyclopentenone PGs
Cayman Chemical 1R 3S3Hydroxycyclopentn 50mg
An antagonist of the 5-HT2C receptor (pKi 9 0) with at least 100-fold more selectivity over other 5-HT dopamine or adrenergic receptors brain penetrant with significant anxiolytic activity used extensively in animal research
Cayman Chemical 4-fluoro BZPhydrochlorIde 50mg
A synthetic enantiomer of the brain-derived oxysterol 24(S)-OH that activates LXRa and LXRB nuclear receptors with slightly reduced potency (EC50 7 and 4 M respectively) compared to the natural isomer (EC50 4 and 3 M respectively)
Cayman Chemical CInamyl3 4dIhydroxyaCyn 50mg
A sodium channel blocker with high-affinity and selectivity for inhibiting human Nav1 8 sodium channels (IC50 8 nM when stimulated at half-maximal inactivation and IC50 79 nM at a resting state) dose dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models
Cayman Chemical MadecasIc AcId 100mg
A thoester substrate analog of 2-AG that can be utlzed for the measurement of MAGL actvty hydrolyss of the thoester bond by MAGL generates a free thol that reacts rapdly wth the chromogenc reagent DTNB resultng n a yellow product wth an absorbance maxmum at 412 nm
Cayman Chemical BYK 191023hydrochlorIde 50mg
A peptidomimetic inhibitor of FTase (IC50 500 pM) selective for FTase over GGTase I (IC50 50 nM) inhibits the growth of NIH3T3 cells expressing RasF at 20 UM reduces tumor growth in a mouse xenograft model using Calu-1 cells that contain a K-Ras oncogenic mutation
Cayman Chemical MBZPhydrochlorIde 100mg
AS-604850 is a selective ATP-competitive inhibitor of PI3KY with IC50 values of 0 25 20 20 and 4 5 UM for the human recombinant Y delta B and a isoforms respectively 13338 AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 UM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42 4 mg/kg 13338
Cayman Chemical LaHydroxyglutarIc AcIdod 50mg
A 5/6 desaturase inhibitor reduces liver arachidonate content by 50 in mice at 3 mg/kg increases mead acid content and inhibits leukotriene C4 synthesis in murine mastocytoma cells at 5 UM
Cayman Chemical Agomelatn 50mg
mmunogen Recombnant human HPGDS Host Rabbt Speces Reactvty ( ) Human mouse Cross Reactvty ( ) HPGDS Applcatons HC WB MW 24 kDa
Cayman Chemical LHomopropargyl GlycInhydr 50mg
A major metabolite of DHA that is produced via oxidation by cytochrome P450 epoxygenases suppresses aggregation and thromboxane synthesis in isolated platelets
Cayman Chemical SaracatInIb 50mg
A potent nhbtor of nuclear transport blocks the nteracton of CRM1 wth NES preventng the export of a broad range of protens nhbts export of mRNA from the nucleus by blockng the nuclear export of mRNAbndng protens blocks the nuclear export of p53 and prevents entry of human normal fbroblasts nto the S phase of the cell cycle thus nhbtng prolferaton orgnally dentfed as an antfungal agent